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KMID : 0043320160390091237
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Archives of Pharmacal Research
2016 Volume.39 No. 9 p.1237 ~ p.1241
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Two new quinones from the roots of Juglans mandshurica
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Jin Mei
Sun Jinfeng
Li Ren
Diao Shengbao
Zhang Changhao
Cui Jiongmo
Son Jong-Keun
Zhou Wei
Li Gao
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Abstract
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Two new quinones, 1-hydroxy-5-pentyl-anthraquinone (1) and 4-(5-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-butyric acid methyl ester (2), together with two known quinones, 5-hydroxy-2-(2-hydroxy-ethylamino)-(1,4) naphthoquinone (3) and juglone (4) were isolated from the roots of Juglans mandshurica (Juglandaceae). Their structures were elucidated on the basis of spectral data. Compound 3 was isolated from the Juglans genus for the first time. Compounds 1?4 exhibited significant cytotoxicity towards cultured MDA-MB231, HepG2 and SNU638 cells with IC50 values ranging from 4.46 to 88.47 μM.
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KEYWORD
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Juglans mandshurica, Juglandaceae, Quinones, Cytotoxicity
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